Direct flights from Chicago to Greenville
All flights from ORD to GSP non-stop. There are direct flights from Chicago O Hare International, Illinois, USA to Greenville-Spartanburg International (GSP), South Carolina, USA every day of the week with United Airlines and American Airlines. The flight distance is 580 miles and the trip usually takes about 1 hour and 47 minutes.
Airlines with non-stop routes:

United Airlines

American Airlines
Flight schedule from Chicago to Greenville with United Airlines
This is a weekly direct flight schedule for United Airlines. Use the arrows or click on the date to change week. Click on any flight departure time to show more information and check availability.
Flight
The timetable & schedule information was updated at 2025-04-22
Flight schedule from Chicago to Greenville with American Airlines
This is a weekly direct flight schedule for American Airlines. Use the arrows or click on the date to change week. Click on any flight departure time to show more information and check availability.
Flight
The timetable & schedule information was updated at 2025-04-22
Chicago to Greenville flight departures
Select a date to see all scheduled flight departures between ORD to GSP.
ORD - GSP information
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Distance580 miles (933 km)
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Flight time1 hour and 47 minutes
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Airlines
United
American Airlines
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AlliancesOne WorldSky TeamStar Alliance
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ClassesEconomyBusinessFirst Class
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United AircraftsAirbus A318 / A319 / A320 / A321Boeing 737 PassengerCanadair (Bombardier) Regional JetEmbraer 170 / 175 / 190 / 195
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American Airlines AircraftsCanadair (Bombardier) Regional JetEmbraer 170 / 175 / 190 / 195
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Departure TerminalsTerminal 1 (United)Terminal 2 (United)Terminal 3 (American Airlines)
Direct flights from Chicago to SC, USA

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MYR Myrtle Beach International Airport

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CAE Columbia Metropolitan