Direct flights from Chicago to Saint Louis
All flights from MDW to STL non-stop. There are direct flights from Chicago Midway International, Illinois, USA to Saint Louis Airport (STL), Missouri, USA every day of the week with Southwest Airlines. The flight distance is 252 miles and the trip usually takes about 1 hour and 15 minutes.
Airlines with non-stop routes:

Southwest Airlines
Flight schedule from Chicago to Saint Louis with Southwest Airlines
This is a weekly direct flight schedule for Southwest Airlines. Use the arrows or click on the date to change week. Click on any flight departure time to show more information and check availability.
Flight
The timetable & schedule information was updated at 2025-04-22
Chicago to Saint Louis flight departures
Select a date to see all scheduled flight departures between MDW to STL.
MDW - STL information
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Distance252 miles (405 km)
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Flight time1 hour and 15 minutes
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Airlines
Southwest
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AlliancesOne WorldSky TeamStar Alliance
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ClassesEconomyBusinessFirst Class
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Southwest AircraftBoeing 737 Passenger
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Arrival TerminalTerminal 2 (Southwest)
Direct flights from Chicago to MO, USA

From Chicago to Kansas City
MCI Kansas City International Airport